Results: Forty-one patients (21 male and 20 female) with Parkinsonâs disease underwent bilateral subthalamic nucleus deep brain stimulation and were followed up for a median interval of 12 months. Deep Brain Stimulation A Surgical Treatment for Parkinsonâs Disease The best treatment options for Parkinsonâs disease vary with the individual patient, and change over the course of the disease. But as the disease progresses, levodopa [â¦] They Deep-brain stimulation of the subthalamic nucleus (STN DBS) is an e! We investi-gated the effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in patients with Parkinson's disease. J Neurosurg 2004; 101: 36â42. Target choice should be tailored to a patientâs individual needs. During DBS surgery, a special wire, called a lead, is inserted into a specific area of the brain. Precise stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for ⦠The brain functional underpinnings of proactive inhi-bition, and notably the role of basal ganglia, are not entirely identified. Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinsonâs disease is known to cause a subtle but important adverse impact on ⦠Unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinsonâs disease improves skeletomotor function assessed clinically, and bilateral STN DBS improves motor function to a significantly greater extent. The mainstays of treatment throughout the disease are drugs such as levodopa that compensate for lost dopamine in the brain. Deep brain stimulation (DBS) is a surgical therapy used for the treatment of Parkinsonâs disease (PD). Schüpbach WM, Chastan N, Welter ML, Houeto JL, Mesnage V, Bonnet AM. Unilateral subthalamic deep brain stimulation in advanced Parkinson's disease. In the 15 years since its introduction into clinical practice, many studies have reported on its benefits, drawbacks, and insufficiencies. Methods The pilot was a prospective, single-blind clinical trial that randomized patients with early-stage PD (Hoehn & Yahr II off medications) to receive bilateral STN DBS plus optimal drug therapy (ODT) vs ODT alone ⦠Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomized. Deep brain stimulation (DBS) of either the subthalamic nucleus (STN) or globus pallidus interna (GPi) is a well-known treatment for patients with motor complications. Skin has become a hot topic in Parkinson's disease (PD) and there has been an exponential growth research over recent years. Deep brain stimulation (DBS) is a surgical procedure to implant a pacemaker-like device that sends electrical signals to brain areas responsible for body movement. Knowledge is still limited regarding the possible impact of STN-DBS on personality traits and the personality characteristics of PD patients who undergo surgery. PMID: 11575287 (Medtronic) FDA. Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease Stimulation of either the GPi or STN improves many features of advanced PD. hypokinetic: ( hÄ«'pÅ-ki-net'ik ), Relating to or characterized by hypokinesis. Download Citation | LesserâKnown Aspects of Deep Brain Stimulation for Parkinson's Disease: Programming Sessions, Hardware Surgeries, Residential Care Admissions, and ⦠Stimulation of either ⦠N. Engl. The surgical option: Deep Brain Stimulation. In the late 1980s, thalamic stimulation was proposed as an alternative to ablative procedures for treating patients with tremor (Benabid et al., 1991). Although several studies have assessed cognitive Our website uses cookies to enhance your experience. [Google Scholar] [Medline] . Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) may prove effective after more than 15 years in patients with Parkinson disease (PD), ⦠Objectives To assess the prevalence and the cumulative incidence of dementia at short-, medium- and long-term follow-up after deep brain stimulation (DBS) of the subthalamic nucleus (STN) (at 1, 5, and 10 years) and to evaluate potential risk factors for postoperative dementia. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinsonâs disease. N Engl J Med. Deep-Brain Stimulation for Parkinsonâs Disease Study Group. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. The lead, which has four electrodes, delivers electrical currents to pmid:28505983; PubMed Central PMCID: PMC5438474. N Engl J Med 2001; 345: 956-963. Reference: Bove F, Mulas D, Cavallieri F, et al. There are three brain targets that have been FDA approved for use in PD. Apraxia of Lid Opening in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's DiseaseâFrequency, Risk Factors and Response to Treatment. In Parkinsonâs disease, deep brain stimulation of the subthalamic nucleus is a successful treatment of motor symptoms, but also might be effective in treating pain. Despite its extensive use, the underlying therapeutic mechanisms of ⦠They Neurology. Although the neural mechanisms underlying benefits and side effects are not well understood, current hypotheses center on the potentially measurable yet currently undefined effects ⦠The procedure is also used to treat essential tremor and dystonia. 4 Timmerman et al. Deep brain stimulation (DBS) is a treatment for symptoms of Parkinson's disease, including tremors, stiffness, and trouble walking.It can also treat side effects of Parkinson's medicines. DBS is an effective symptomatic treatment that improves function and quality of life in PD, regardless of whether the therapy uses constant-voltage or constant-current devices. The Deep-Brain Stimulation for Parkinson's Disease Study Group. RůžiÄka, F. et al. Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: An open-label randomised, controlled trial. Neurosurg Clin N Am. need for response suppression. Based on advancements in the understanding of the pathophysiology of the disease, especially in animal models, the subthalamic nucleus has been pointed as a major target for deep brain stimulation in the treatment of motor symptoms, first developed in non-human primate and then successfully transfered to parkinsonian patients. Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinsonâs disease. Background Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized treatment in Parkinsonâs disease (PD). THURSDAY, June 3, 2021 (HealthDay News) -- For patients with Parkinson disease (PD), deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective beyond 15 years after implantation, according to a study published online June 2 in Neurology.. Francesco Bove, M.D., from CHU Grenoble Alpes in France, and colleagues used data from before surgery, at one year, and ⦠Specifically with DBS, a clinical trial published in 2018 has shown that behavioral outcomes are better in young patients who are treated using traditional deep brain stimulation with medication than with medication alone. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN-HFS) is the preferred surgical treatment for advanced Parkinson's disease. Unilateral stimulation of the subthalamic nucleus in Parkinson disease: a double-blind 12-month evaluation study. View Article PubMed/NCBI Google Scholar 4. Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects. Deep brain stimulation (DBS) of the sub-thalamic nucleus (STN) or globus pallidus internus (GPi) is a common treatment for Parkinson's disease and various dystonias [12, 13]. Volkmann J, Allert N, Voges J, et al. The Deep-Brain Stimulation for Parkinsonâs Disease Study Group. The site of permanent stimulation is the subject of ongoing debate, as stimulation both within and adjacent to the subthalamic nucleus ⦠2021 Feb 3;12(1):779. doi: 10.1038/s41467-021-21022-9. The optimal propofol anesthesia for asleep DBS is unknown. OBJECTIVE: We performed a two-year prospective study on PD patients who underwent STN-DBS and analyzed changes in speech function to clarify factors predicting for Reference: Bove F, Mulas D, Cavallieri F, et al. Deep Brain Stimulation (DBS) is the standard of care for Parkinson's disease (PD) patients with severe motor complications. 2001; 345: 956-963.CrossRef Google Scholar PubMed Nat Commun. Crossref, Medline, Google Scholar; 16 Linazasoro G, Van Blercom N, Lasa A. From its origins to clinical approval, the history of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinsonâs disease (PD) has been one of extreme success. But as the disease progresses, levodopa [â¦] N ⦠However, longitudinal speech changes after STN-DBS are not fully understood. Importance Selection of the best deep brain stimulation (DBS) targetâsubthalamic nucleus (STN) or globus pallidus interna (GPi)âfor treatment of motor complications in Parkinson disease remains a matter of debate.. Observations Increasing evidence from randomized clinical trials indicates that motor benefit is similar between both targets, including an effect on dyskinesia and ⦠A small fraction of patients will fail to respond to DBS, develop psychiatric and cognitive side-effects, or incur surgery-related complications such as infections and hemorrhagic events. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinsonâs disease. Forty-one patients (21 male and 20 female) with Parkinsonâs disease underwent bilateral subthalamic nucleus deep brain stimulation and were followed up for a median interval of 12 months. However, its effects on STN activity and neuropsychological outcomes are controversial. Deep brain stimulation (DBS) is a neurosurgical procedure involving the placement of a medical device called a neurostimulator (sometimes referred to as a "brain pacemaker"), which sends electrical impulses, through implanted electrodes, to specific targets in the brain (brain nuclei) for the treatment of movement disorders, including Parkinson's disease, essential tremor, and dystonia. [Medline] . 17. [17] Yágüez et al. ⢠Bilateral stimulation of the subthalamic nucleus (STN) as an adjunctive therapy in reducing some of the symptoms of moderate to advanced levodopa-responsive Parkinsonâs disease (PD) that are not adequately controlled with medication. For example, deep brain stimulation of subthalamic nucleus is effective for all major movement symptoms of Parkinson's disease, such as tremor, slowness of movement (bradykinesia), stiffness (rigidity), and problems with walking and balance. However, it has been unclear which type of pain may benefit and how neurostimulation of the subthalamic nucleus might interfere with pain processing in Parkinsonâs disease. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Pallidal versus Subthalamic Deep-Brain Stimulation for Parkinsons Disease. During DBS surgery, a special wire, called a lead, is inserted into a specific area of the brain. THURSDAY, June 3, 2021 (HealthDay News) â For patients with Parkinson disease (PD), deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective beyond 15 years after implantation, according to a study published online June 2 in Neurology.. Francesco Bove, M.D., from CHU Grenoble Alpes in France, and colleagues used data from before surgery, at one year, and ⦠REVIEWARTICLE Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinsonâs disease Casey H. Halpern1, Jacqueline H. Rick2, Shabbar F. Danish3, Murray Grossman4 and Gordon H. Baltuch1* 1Department of Neurosurgery, Neurology and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA 2Department of Psychiatry, University of ⦠The authors analyze long-term outcome in a substantial number of patients who underwent subthalamic nucleus (STN) deep brain stimulation (DBS) surgery under general anesthesia. doi: 10.1056/nejmoa0907083. Tailoring Subthalamic Nucleus Deep Brain Stimulation for Parkinson For the whole group, the mean improvements of Unified Parkinsonâs Disease Rating Scale (UPDRS) parts II and III were 32.5% and 31.5%, respectively (P<0.001). In the 15 years since its introduction into clinical practice, many studies have reported on its benefits, drawbacks, and insufficiencies. 2009).What remains unclear is how local STN neurons respond to DBS and how this effect is ⦠Deep brain stimulation of the subthalamic nucleus was approved by the FDA as a treatment for Parkinsonâs in 2002. subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. Of the 251 participants, 124 were assigned to receive medical therapy plus bilateral subthalamic stimulation. The benefit of subthalamic deep brain stimulation for pain in Parkinson disease: a 2-year follow-up study. 2017;7(2):235â45. We assessed whether globus pallidus pars interna (GPi) deep brain stimulation (DBS) gives greater functional improvement than does subthalamic nucleus (STN) DBS. The subthalamic nucleus has been implicated in mood disorders in PD patients, as deep brain stimulation (DBS) has been found to have antidepressant, depressive and mania-inducing effects (Takeshita et al 2005). Propofol is a general anesthetic option for deep brain stimulation (DBS) of the subthalamic nucleus (STN) of patients with Parkinsonâs disease (PD). Abstract Objectives:To assess the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with advanced Parkinson's disease previously reliant on apomorphine as their main antiparkinsonian medication. Background: The subthalamic nucleus is the preferred target for deep brain stimulation in patients with advanced Parkinsonâs disease. More than 100,000 patients have had electrodes surgically implanted into that region and typically undergo continuous high-frequency stimulation without adverse effects. Deep brain stimulation has been approved by the FDA as an adjunctive treatment in Parkinson disease, especially aimed at controlling these complications. BackgroundDeep brain stimulation of the subthalamic nucleus (STN) improves motor symptoms of Parkinson disease. 2021. doi: 10.1212/WNL.0000000000012246 This article has been republished from the following materials. The benefit of subthalamic deep brain stimulation for pain in Parkinson disease: a 2-year follow-up study. Cognitive predictors of cognitive change following bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease: 2014: To specifically establish a detailed neuropsychological profile before and after STN-DBS and identify any pre-surgical cognitive profile that can predict cognitive outcomes after stimulation. 1â5 Furthermore, DBS may even benefit patients relatively early in the disease ⦠Study selection. We investi-gated the effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in patients with Parkinson's disease. Deep brain stimulation (DBS) of the subthalamic nucleus is an established therapeutic option for managing motor symptoms of Parkinsonâs disease. Lancet Neurology. ciated with subthalamic nucleus stimulation in Parkinsonâs disease. Patients with Parkinson's disease (PD) often lose weight, but after subthalamic nucleus deep brain stimulation (STN-DBS), they gain weight. Targeting the subthalamic nucleus for deep brain stimulation--a comparative study between magnetic resonance images alone and fusion with computed tomographic images. This study was conducted as a multi-center clinical trial for patients with idiopathic Parkinsonâs disease. Pallidal versus Subthalamic Deep-Brain Stimulation for Parkinsons Disease. In 39 patients with complete long-term data, subthalamic nucleus deep brain stimulation improved motor fluctuations and dyskinesia scores on the Unified Parkinson's Disease ⦠DBS surgery includes subthalamic nucleus (STN) stimulation, globus pallidus interna (GPi) stimulation, and thalamic deep brain stimulation (see the following images). Stimulation of the subthalamic nucleus in Parkinson's disease: A 5 year follow up. 11(2): 140-149. There are three areas in the brain that can be targets for deep brain stimulation in patients with Parkinsonâs disease. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. need for response suppression. THURSDAY, June 3, 2021 (HealthDay News) -- For patients with Parkinson disease (PD), deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective beyond 15 years after implantation, according to a study published online June 2 in Neurology.. Francesco Bove, M.D., from CHU Grenoble Alpes in France, and colleagues used data from before surgery, at one year, and ⦠The clinical efficacy of deep brain stimulation (DBS) in the subthalamic nucleus (STN) for treating many of the symptoms of Parkinson's disease is now well documented (Deep Brain Stimulation for Parkinson's Disease Study Group 2001; Weaver et al. For the study, researchers set out to learn about how well people with Parkinsonâs disease do over the long term after trying bilateral subthalamic nucleus deep brain stimulation, a treatment that was approved by the Food and Drug Administration (FDA) for treating advanced Parkinsonâs disease about 20 years ago. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. Deep-Brain Stimulation for Parkinson's Disease Study Group, Obeso JA, Olanow CW, Rodriguez-Oroz MC, Krack P, Kumar R, Lang AE. 2011 Jan. 75(1):132-7; discussion 22-4, 29-31. Deep brain stimulation, electrical stimulation of targeted brain ⦠They are the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus of the thalamus. Neurosurgery . Deep brain stimulation (DBS) surgery was first approved in 1997 to treat Parkinsonâs disease (PD) tremor, then in 2002 for the treatment of advanced Parkinson's symptoms. Neurology. Note: material may have been edited for length and content. The UK National Collaborating Centre for Chronic Conditions notes the following indications for STN and GPi in patients with Parkinson disease [ 23 ] : Objective: To evaluate the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson disease (PD) patients on motor complications beyond 15 years after surgery. Listing a study does not mean it has been evaluated by the U.S. Federal Government. The thalamus is a key relay station for sensory information flowing into the brain and filters out information of particular importance from the mass of signals entering the brain. The ventralis intermediate nucleus (Vim) of the thalamus is one of three potential targets for deep brain stimulation (DBS). Subthalamic nucleus stimulation is a new application of the original deep brain stimulation technique. At seven Veterans Affairs and six university hospitals, we randomly assigned 299 patients with idiopathic Parkinson's disease to undergo either pallidal stimulation (152 patients) or subthalamic stimulation (147 patients). Introduction. 2009. Examples of these disorders include Parkinson's disease, Huntington disease, dystonia (involuntary muscle contractions), Tourette syndrome, and multiple system atrophy (neurodegenerative disorder). 2001 Sep 27;345(13):956-63. Deep brain stimulation (DBS) is a surgical therapy used for the treatment of Parkinsonâs disease (PD). The lack of alarms to alert the end-of-battery life in older models and delays in implantable pulse generator (IPG) replacement can result in fatal complications in patients who do not regularly monitor battery status. INTRODUCTION. Deep brain stimulation (DBS) of the subthalamic nucleus is a neurosurgical intervention for Parkinsonâs disease patients who no longer appropriately respond to drug treatments. Epub 2017/05/17. The mechanism underlying the benefit for the motor symptoms in PD is relat ⦠Methods Eighty-two patients underwent bilateral placement of DBS electrodes under general anesthesia for advanced Parkinson disease; the STN was the target in all cases. Deep brain stimulation (DBS) of the sub-thalamic nucleus (STN) or globus pallidus internus (GPi) is a common treatment for Parkinson's disease and various dystonias [12, 13]. Which is the best targetâglobus pallidus internus (GPi) or subthalamic nucleus (STN)âis still a matter of discussion. Note: material may have been edited for length and content. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) is FDA approved and has been shown to be effective in reducing motor symptoms of PD. 2012 Jan. 70(1):18-23; discussion 23-4. 2005. It is premature to exclude GPi as an appropriate target for DBS in patients with advanced disease. AO. World Neurosurg . Haslinger B, Kalteis K, Boecker H, Alesch F, Ceballos-Baumann brain stimulation on executive function in Parkinsonâs disease. Deep brain stimulation (DBS) is a neurosurgical procedure involving the placement of a medical device called a neurostimulator (sometimes referred to as a "brain pacemaker"), which sends electrical impulses, through implanted electrodes, to specific targets in the brain (brain nuclei) for the treatment of movement disorders, including Parkinson's disease, essential tremor, and dystonia. Background. Background: Deep brain stimulation (DBS) of the subthalamic nucleus is an established therapeutic option for managing motor symptoms of Parkinson's disease. 14. (2010). Deep brain stimulation (DBS) is a surgical procedure used to treat several disabling neurological symptomsâmost commonly the debilitating motor symptoms of Parkinsonâs disease (PD), such as tremor, rigidity, stiffness, slowed movement, and walking problems. Objective: To evaluate the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson disease (PD) patients on motor complications beyond 15 years after surgery. Qualitative reviews have concluded that diminished verbal fluency is common after STN DBS, but that changes in global cognitive abilities, attention, executive functions, and memory are only inconsistently observed and, when present, often ⦠Objective To report 5-year outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early-stage Parkinson disease (PD) pilot clinical trial. 2012 Jan. 70(1):18-23; discussion 23-4. Aug. 8, 2011 -- A new study shows that Parkinsonâs disease patients treated with deep brain stimulation can expect the technology to control symptoms like tremors for a ⦠We compared daily energy intake (DEI), resting energy expenditure (REE) and substrate oxidation rates (measured by indirect calorimetry) in nineteen STN-DBS-treated patients (Group S), thirteen others on pharmacologic treatment by levodopa (Group L) ⦠Long-term outcomes (15 years) after subthalamic nucleus deep brain stimulation in patients with parkinson disease. Dementia and subthalamic deep brain stimulation in Parkinson disease: A long-term overview In patients with PD with longstanding STN-DBS, dementia prevalence and incidence are not higher than those reported in the general PD population. Implantation of deep brain stimulator electrodes using interventional MRI. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) may prove effective after more than 15 years in patients with Parkinson disease (PD), ⦠Purpose The settings of 3 electrical stimulation parameters were adjusted in 12 speakers with Parkinson's disease (PD) with deep brain stimulation of the subthalamic nucleus (STN-DBS) to examine their effects on vowel acoustics and speech intelligibility. Each of these areas plays a role in the brainâs circuitry that is responsible for the control of movement. Over the last three decades, extensive basic and clinical research has been performed on the use of subthalamic nucleus (STN) as the preferred deep brain stimulation (DBS) target for the treatment of Parkinson's disease (PD). Deep Brain Stimulation (DBS) For Parkinson's Disease: Caudal Zona Incerta Versus Subthalamic Nucleus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. 76: 1640-4. Initially, this method retrieved 345 studies ().To refine the search, the following topics were selected: âParkinsonâs Diseaseâ, âSubthalamic Nucleusâ, âDeep Brain Stimulationâ, âDBSâ, âCognitionâ (263), published on the Medline/Pubmed database (223) between 2007 and 2017 (195). ) can be a highly effective therapy for Parkinson's disease (P 2012. Background: Patients with advanced Parkinson's disease often have rapid swings between mobility and immobility, and many respond unsatisfactorily to adjustments in pharmacological treatment. Dayal V, Limousin P, Foltynie T. Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: The Effect of Varying Stimulation Parameters. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Deep brain stimulation (DBS) can lessen motor function impairments and reduce the need for medication for up to 10 years in people with Parkinsonâs disease (PD), a new study shows. Frequency-correlated decreases of motor cortex activity asso- Brain 2000;123:1142â1154. New England Journal of Medicine, 362(22), 2077â2091. The purpose of this study is to investigate the effects of subthalamic nucleus and globus pallidus interna deep brain stimulation on bowel symptoms and the ability to smell things in patients with Parkinson disease and constipation. Methods The pilot was a prospective, single-blind clinical trial that randomized patients with early-stage PD (Hoehn & Yahr II off medications) to receive bilateral STN DBS plus optimal drug therapy (ODT) vs ODT alone ⦠N Engl J Med. Chronic high-frequency deep brain stimulation (DBS) has been a standard surgical treatment to the Parkinsonâs disease (PD) patients. Chronic deep brain stimulation of the subthalamic nucleus for Parkinsonâs disease: effects on cognition, mood, anxiety and personality traits. The most commonly utilized brain targets include the subthalamic nucleus (STN) and the globus pallidus interna (GPi). Psychoneuroendocrinology 52 , 302â310 (2015). Unpublished observations from our clinic noted that some subthalamic nucleus deep brain stimulation patients complain of post-operative dyspnea. Little is known about the relationship between electrode contact location and mood response. Some patients with Parkinsonâs disease may benefit from deep brain stimulation (DBS), a surgical therapy that has been FDA approved for over a decade. The lead, which has four electrodes, delivers electrical currents to
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