Further, we demonstrate that the fibrinogen recognition still occurs in competitive binding assays, starting from testing in the presence of albumin, which is a common agent for surface passivation and blocking of non- Molecular Weight 3163.10. Synonym: tris-NTA trifluoracetic acid salt, tris-NTA trifluoroacetate salt solution. Theranostics 2021, ... PPa is the molecular weight of PPa, CTXM is the molecular weight of CTX, M CTX-S-CTX is the molecular weight … 3. Purity. 1,2,3 DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications. 4 It can be conjugated to a variety of … Ea273dspEΔ1521 cells encode a DspE derivative of 145 kDa with an internal deletion corresponding to residues T 1064 to V 1570. Folate-derivatized PEG-DSPE (F-PEG 2000-, F-PEG 3400-, and F-PEG 5000-DSPE), which are conjugates of folic acid and amino-PEG-DSPE, were synthesized as reported previously [13, 15]. Application Notes: This product has been used for creating micelles that are able to carry drugs with low solubility. Ea273dspEΔ1521 cells encode a DspE derivative of 145 kDa with an internal deletion corresponding to residues T 1064 to V 1570. GPC was also used for determining molecular weight of PEOz-N 3. Molecular Weight: 1049.04. Ea273dspED1521 cells encode a DspE derivative of 145 kDa with an internal deletion corresponding to residues T 1064 to V 1570. Revision: 08/18/2019 Page: 2 of 5 DSPE-MPEG(2000) (sodium salt) SAFETY DATA SHEET Section 4. PCNZ-003. Appearance. When lipids are placed in contact with water, the unfavorable interactions of the hydrophobic segments of … For these experiments, 10 mg of mPEG was mixed with ∼1 mg BNNTs in 5 mL of DI water, whereas 5 mg DSPE was mixed with 1 mg BNNTs in5mLofDI water. Partnership with HTL. Box B, Frederick, Maryland 21702. 350/550/750/1000/2000/3400/5000/10000. The starting material DSPE-PEG-COOH shows a pattern spanning between molecular weights 2630 and 2985, with a peak at molecular weight 2718. CAS Registry Number is a Registered Trademark of the American Chemical Society. 474922-22-0. HTL Partnership. The hydrophilic PEG linker can increase the water solubility of the overall compound … The manufacturing process involves a sterile filtration step using a filter that has been validated. Structure: PEG Molecular Weight: 1,000 Da : Functional Group: DSPE : Fluorophores: FITC : Related Products. The peak for the product was considered 3147 [2718 + 429 (contributed from HP)] and was accepted as the molecular weight of the product for the mole calculations hereafter. Package Size: 1g/bottle、10g/bottle. A new band showed up around 30 kDa ( Lane 2) and the change of molecular weight was as expected since the molecular weight of DSPE-PEG2000 -DBCO is around 3 kDa. DSPE-PEG-NHS. This protein was present in the culture supernatant of this strain, suggesting that the missing residues are not required for secretion of DspE. The weight ratio of latex: PEG-DSPE:Rho-PE was 1:10:0.1. Storage: 12months after receival at -20°C in the dark. The molecule consists of the macrocycle 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) that is coupled to a single molecular weight, discrete polyethylene glycol (dPEG®) linker and … Materials and Equipment. MPEG-2000-DSPE - CAS 147867-65-0 Catalog number: 147867-65-0. This protein was present in the culture supernatant of this strain, suggesting that the missing residues are not required for secretion of DspE. Form. 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [succinimidyl (polyethylene glycol)] Molecular weight (PEG) Choose an option 600 1000 2000 3400 5000. For every step of your research, from bench to clinic, we can help. 147867-65-0. F5-maleimide-PEG-DSPE conjugate at a ratio of 10 Ag protein/Amol liposomal phospholipid (9–11). Reaction prod-ucts were freeze-dried at −40 C and the molecular weight of Applications: an ionizable amino lipid, is a potent siRNA delivery vehicle. DSPE-PEG-NHS. -20°C. Inclusion of 5 mole% of DSPE-PEG(2000) or 45 mole% cholesterol to DSPC liposomes increased the mean plasma area under the curve (AUC(0-24h)) 19-fold and 10-fold, respectively. B, outline of conjugation of the reduced scFv containing a reactive sulfhydryl group with DSPE-PEG-Mal–activated liposomes. Learn More. DSPE PEG, mPEG-DSPE. Cat No. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively … Store under desiccating conditions. Shop a large selection of products and learn more about Avanti Polar Lipids DSPE-PEG 2000 AMINE 100MG DSPE-PEG 2000 AMINE 100MG . Binding kinetics of a specific anti-indium-DTPA antibody (clone 734) were monitored using the BIAcore system and the kinetic parameters were calculated by curve fitting. Package size. In Vitro. Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. The 1 H-NMR spectrum of DSPE-PEG-PEI in D 2 O exhibited characteristic peaks at 2.5–3.0 ppm (peaks of PEI), 3.6 ppm (peaks of PEG) and 1.0–1.5 ppm (peaks of DSPE), indicating that PEI was successfully introduced to the DSPE-PEG-NHS molecular. DSPE-PEG8-Mal contains a DSPE and maleimide group. DSPE-PEG-NHS,1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- (polyethylene glycol) -NHS (sodium salt) can be conjugated with peptides, antibodies, or proteins which contain Amine groups on the surface. Khan AK, Ho JCS, Roy S, Liedberg B, Nallani M. Facile Mixing of Phospholipids Promotes Self-Assembly of Low-Molecular-Weight Biodegradable Block Co-Polymers into Functional Vesicular Architectures. Purity:95%. (DSPC),cholesterol(Chol),DSPE-DTPAthatvariedintheir PEG content and molecular weight (2000, 1000, or 750). Lipodisks based on DSPE-PEG 1000 display, on the other hand, a structural behavior very similar to that observed with DSPE-PEG 5000 and DSPE-PEG 2000. The product is designed for use in liposomes and micelles where a fluorescent … The actual formation of the liposomes is standard. Storage Temperature. The molecular weight doi: 10.3390/polym12040979. JenKem Technology offers Methoxy PEG DSPE (M-PEG DSPE), a high quality lipid PEG designed for liposome formation. For instance, 0.25F5-NL indicates liposomes with 0.25 mol% F-PEG 5000-DSPE of total lipids, and 0.25F5-SL indicates liposomes with total 2.5 mol% PEG-lipids composed of 2.25 mol% mPEG 2000-DSPE for steric stabilization and 0.25 mol% F-PEG 5000-DSPE. Empirical Formula (Hill Notation): C43H68N8O22. 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [amino (polyethylene glycol)] (DSPE-PEG-NH2) Molecular weight. HTL Partnership. As discussed above, the nanoparticles made from DSPE-PEG have sizes in the range of 30–90 nm, which are smaller than those with PLGA because of the higher amphiphilicity and lower molecular weight of DSPE-PEG. JenKem Technology offers Methoxy PEG DSPE (M-PEG DSPE), a high quality lipid PEG designed for liposome formation. 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE)-polyethylene glycol-amine (DSPE-PEG-Amine, DSPE-PEG-NH2) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an amine. DSPE-PEG-NH2 is used to modify liposome surface with biomolecules containing amine reactive groups (NHS, thiolate). The objective of this study was to investigate the influence of the thermosensitive liposomal formulation on the encapsulation and release of low and high molecular weight hydrophilic drugs, in order to identify the key parameters to control during nanocarrier design, depending on … Product Name:α-Succinimidyl-ω-distearoyl-sn-glycero-3-phosphoethanolamino poly (ethylene glycol) Abbrevition:DSPE-PEG-NHS. Methoxy PEG DSPE from JenKem Technology is available with MW 5,000 Da (M-DSPE-5000), in 1g and 10g packing sizes. 748.07. Molecular formula: C44H87NO5. The DSPE-Cy5 A and B present high EE under the absorption loading strategy, reaching values as high as ~80%. DOX-LTSL-CREKA, composed of DPPC, MSPC, DSPE-PEG, and DSPE-PEG-CREKA (86:10:2:2 molar ratio), was prepared by a thin-film hydration method ( B ). It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents. Acronym: DSPE-NHS Chemical Name: N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Distearoyl CAS#: Molecular weight: 981.2 Alkyl composition: R 1 COO= C18:0, R 2 COO= C18:0 Package size: 100mg or 1g amber glass bottle. Revision: 08/18/2019 Page: 2 of 5 DSPE-MPEG(2000) (sodium salt) SAFETY DATA SHEET Section 4. The increased 3 kDa in DSPE-PEG2000-ScFv complex was just the theoretical MW of malDSPE-PEG2000, suggesting that DSPE … a certain volume of the remaining solution was freeze-dried, and the It … DSPE PEG NHS can be easily incorporated into liposome NACRES NA.25. We used this cysteine residue to react with DSPE-PEG2000 containing a maleimide functional group (DSPE-PEG2000-Mal; Fig. According to the element analysis, the amount of 7pep-DSPE-PEG 2000 in the final product was 60.3%. PubMed ID: … molecular weight of 2000 Da (PEG 2000). 2005-03-26. Calculate = Background. Binding kinetics of a specific anti-indium-DTPA antibody (clone 734) were monitored using the BIAcore … The difference in molecular weight indicates the successful connection of iRGD and DSPE-PEG-Mal. The proportion of flexible components projecti ng Inthiscase,moremPEG was used to increase its concentration due to its larger molecular weight. Mechanical properties of giant unilamellar DPPC vesicles containing varying concentrations of DSPE-PEG (PEG MW: 550, 1000 and … Exact Mass. ≥80.0% (HPLC) Sigma-Aldrich. Calculate = Background. After 12 h at 4 C the reaction was stoppedbyaddingenough0.1Mglycinesolutiontoconsumethe remaining-NHS moieties of DSPE-PEG-NHS. Learn More. ADS645WS-loaded nanoparticles were concentrated in a stirred ultrafiltration cell on an Amicon YM100 membrane (Millipore, Billerica, MA) to reach a concentration of 40 to 44 mmol/L of phospholipid. Folate receptors are cellular surface markers for numerous solid tumors and myeloid leukemias. Folic acid is an essential … Polymers (Basel). DSPE-PEG-NHS, MW 3400. 2941.605 (average MW due to polydispersity of PEG) Purity. Description. The experimental molecular weight (MW) of ScFv and DSPE-PEG2000-ScFv were 26 kDa and 29 kDa (Fig. Product name & molecular weight; mPEG-DSPE (PEGylated Phospholipid) PLS-2044 : mPEG-DSPE, MW 5k : PLS-2045 : mPEG-DSPE, MW 2k : PLS-2046 : mPEG-DSPE, MW 1k : PLS-2047 : mPEG-DSPE, MW 550 : PSB-2040 : mPEG-DSPE, MW 40k : PSB-2041 : mPEG-DSPE, MW 30k : PSB-2042 : mPEG-DSPE, MW 20k : PSB-2043 : mPEG-DSPE… Nanocs now provides cGMP grade mPEG DSPE products with the molecular weight ranges from 750 to 5000. Methoxy PEG DSPE with superior quality specification of ≥95% Substitution. Several faint bands of lower molecular weight were present in cell fractions. TFP-dPEG ® 13-DSPE, product number 11029 (PN11029), is designed for use in liposomes and micelles.The lipophilic end of the molecule is the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) modified by conjugation to a single molecular weight, discrete polyethylene glycol (dPEG ®) chain.The dPEG ® spacer is functionalized as a 2,3,5,6 … First Aid Measures Description of First Aid Measures: Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. By comparing immobilization of lipodisks stabilized with DSPE-PEG1000, DSPE-PEG2000, and DSPE-PEG5000 to porous and smooth silica surfaces, we show that the amount of surface bound disks can be considerably improved by the use of PEG-lipids with reduced molecular weight. Search for more papers by this author. While most PEG products are a mixture of different molecular weights, PurePEG supplies monodisperse, sin gle molecular weight molecules. Powder or Chloroform. Preparation and Physicochemical Characteristics of Drug-Loaded Nanoparticles Composition. PurePEG specializes in supplying PEG reagents with discrete molecular weights, offering PEG reagents with up to min.99% purity. Molecular weight: 710.17. Gram‐Scale Production and Purification. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. 147867-65-0 - MPEG-2000-DSPE - Similar structures search, synonyms, formulas, resource links, and other chemical information. Methoxy PEG DSPE from JenKem Technology is available with MW 5,000 Da (M-DSPE … Stealth Liposomes (PEGylated Liposomes) as Drug Carrier System for Drug Delivery. It is an amphi - philic linear polymer with a low CMC and can still form micelles at a lower concentration [16], and the PEG fragments of PEG 2000-DSPE … 102547. For these experiments, 10 mg of mPEG was mixed with ∼1 mg BNNTs in 5 mL of DI water, whereas 5 mg DSPE was mixed with 1 mg BNNTs in5mLofDI water. However, because low molecular weight drugs can rapidly pass into the bloodstream after intratumoral in-jection and because the retention time of such drugs in ... (DSPE) and DSPE-PEI liposomes were HSPC/CHOL (4 mg of lipid) and HSPC/CHOL/DSPE-PEI (0.1 mg, 0.4 mg, 0.7 mg, and 1 mg of DSPE-PEI based on HSPC/CHOL Product Number Product Description SDS; QBD10868: Pricing: Match Criteria: Product Name, Keyword. MPEG-2000-DSPE is a phospholipid containing a polyether unit. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. CAS No. 1 Year. Min.Order: 100 Kilogram FOB Price: USD $ 1.0-5.0/Kilogram Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. Fluorescein labeled DSPE PEG products emitted green fluorescence and can be easily detected with fluorescent microscopy or spectroscopy. ※ This product is for research use only and is not intended for use in humans or for diagnostic use. The DSPE-PEGs have been FDA approved for medical applications. molecular weight of DSPE-PEG-NHS plus sodium ions, and the blue peak represents the molecular weight of DSPE-PEG-NHS plus potassium ions. -DSPE or Flu-PEG 5000-DSPE, 3 m M Flu-PEG 10000-DSPE, or 0.1% Triton X (negative control) for 4 h at 37°C. : 1069-79-0, MW: 748.07 g/mol), respectively. Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. ※ This product is for research use only and is not intended for use in humans or for diagnostic use. Slide 1 (about us) Design, Develop, Discover. Support custom synthesis.Fast Shipping. Molecular Formula. MPEG-2000-DSPE 147867-65-0 N-(Carbamoyl-methoxy peg-40)-1,2-distearoyl-cephalin sodium UNII-3L6NN8ZZKU UNII-IC5THO9L3U More... Molecular Weight 872.1 g/mol Parent Compound CID 86278270 Component Compounds CID 5360545 (Sodium) CID 86278270 Dates Modify 2021-04-10 Create 2014-11-22 Contents 1 StructuresExpand this section When calculating molecular weight of a chemical compound, it tells us how many grams are in one mole of that substance. Inthiscase,moremPEG was used to increase its concentration due to its larger molecular weight. aggregation, molecular weight, protein hydrophobicity or any other non-selective mechanism. Mar. DSPE-PEG5-propargyl CAS# 2112737-93-4 formule: C55H104NO14P purity: ≥95%. The product contains a lipophilic tail of 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and a hydrophilic head consisting of a methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®). * Please be kindly noted products are not for therapeutic use. >99%. F5-maleimide-PEG-DSPE conjugate at a ratio of 10 Ag protein/Amol liposomal phospholipid (9–11). The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. Buy high quality 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine 1069-79-0 from toronto research chemicals Inc. Molecular Weight: 872.135911 Formula: (C 2 H 4 O)n.C 43 H 84 NO 10 P Name: MPEG-2000-DSPE Synonyms: 3L6NN8ZZKU; IC5THO9L3U; 71CN34B25W; 156543-00-9; 247925-28-6; 147867-65-0; DSPE-mPEG2000; DSPE-mPEG-2000; MPEG-2000-DSPE; UNII-71CN34B25W; UNII-3L6NN8ZZKU; UNII-IC5THO9L3U; MPRG-2000-DSPE … Succinimidyl ester (NHS) on the PEG terminal reacts with primary amine groups efficiently at pH 8~10. dspe-peg 5000-oh DSPE-PEG 5000-OH is DSPE-PEG 5000 with a hydroxy group. « hide 10 20 30 40 50 melkslgteh kaavhtaahn pvghgvalqq gssssspqna aaslaaegkn 60 70 80 90 100 rgkmprihqp staadgisaa hqqkksfslr gclgtkkfsr sapqgqpgtt 110 120 130 140 150 hskgatlrdl larddgetqh eaaapdaarl trsggvkrrn mddmagrpmv 160 170 180 190 200 kggsgedkvp tqqkrhqlnn fgqmrqtmls kmahpasana gdrlqhspph 210 220 230 240 250 ipgshheike epvgstskat tahadrveia … 1B). 9004-74-4, MW: 5000 g/mol) and DSPE (Sigma-Aldrich, CAS no. PBS buffer was changed every 24 h during the whole dialysis process. The use of DSPE-PEGn-NH 2 linker 124 with various molecular weight (MW) PEG chains (that is, with various n values) causes dye-linker structure 124, 126 to emit at different fluorescence intensity and fluorescence quantum yield (QY). Please contact us at [email protected] for quotation and availability. Da in molecular weight and its monomer can be excreted by the kidney. Storage and Stability information ： Solubility ： Dissolve in DMSO Chloroform or Methanol. The molecular weight of PEOz1-N 3, PEOz2-N 3 and PEOz3-N 3 were 2247, 3923 and 7139 . pricing. Notes: The schematic representation of synthesis of DSPE-PEG-CREKA ( A ). The high molecular weight fractions were put into a cellulose tube (MW cut‑off 12,000), and dialyzed against water at 4˚C to obtain aqueous solution of oxidized S (oxccS). CAS Number: 862778-60-7 (free acid) 14136. Cryo-transmission electron micrographs of IDA loaded liposomes indicated that the drug formed a precipitate within liposomes. C139H271N4O57P (average MW due to polydispersity of PEG) Empirical Formula (Hill Notation) C152H306N3O58PSi. Name: mPEG2000-DSPE CAS#: 147867-65-0 Chemical Formula: C45H87NNaO11P Exact Mass: 871.5914 Molecular Weight: 872.15 Elemental Analysis: C, 61.97; H, 10.06; N, 1.61; Na, 2.64; O, 20.18; P, 3.55 On the molecular level, ... show no symptoms induced by either the hrpL or dspE mutant, compared to the WT. 350/550/750/1000/2000/3400/5000/10000. Folic acid is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. DSPE-PEG47-acid. 9004-74-4, MW: 5000 g/mol) and DSPE (Sigma-Aldrich, CAS no. Drugs 2019, 17, x 3 of 11 confirm that the TxID has a molecular weight of 1489.00 Da with m/z of 746.25 Da [M + 2H]2+, which is consistent with its theoretical … Methoxy PEG DSPE with superior quality specification of ≥95% Substitution. Stearic acid-PEG-FITC Catalog: CDN2161. The same ratio of DSPC to PEG monomer units (DSPC/monomer unit of ethylene glycol = … Formula Weight. On the country, Monodisperse PEG refers to polyethylene glycol (PEG) with a precise, discrete molecular weight (ie, with a fixed molecular weight … Storage:-20 ℃ Stability ： 12months . Formulations containing DSPE-MPEG(2000) have been … The lipophilic tail of the molecule contains 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE… DSPE-MPEG-2000 has proven exceptionally useful due to certain characteristics such as good stability, longevity, and ability to accumulate in areas with abnormal vasculature, including tumors 2,3 which have leaky vasculature. 4b), respectively. At each data point, NP solutions The DOX/lipid (w/w) ratio was 1:20. 7628 Langmuir 2001, 17, 7628-7636 Protein-Induced Changes in Poly(ethylene glycol) Brushes: Molecular Weight and Temperature Dependence N. V. Efremova,‡ S. R. Sheth,† and D. E. Leckband* Department of Chemical Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801 Received March 16, 2001. 2020 Apr 22;12(4):E979. The band was smeared because of the molecular weight … When the PEG molecular weight was increased, the PEG peak became sharp, indicating that long-chain PEGs were more flexible on the liposome surface. SAIC‐Frederick, Inc., National Cancer Institute at Frederick, P.O. 1,2-Distearoylphosphatidylethanolamine | C41H82NO8P - PubChem
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